Can I Use Two Different Serums for Day and Night? [Expert Tips]
This article will help readers understand the benefits of using different serums for day and night, how to layer them correctly, and why Decree Serums are an excellent choice for creating a balanced skincare routine.
- Can I Use Two Different Serums for Day and Night?
- Benefits of Using Separate Serums for Day and Night
- Why Separate Serums Are Effective
- Can I Use Two Different Serums at the Same Time or Mix Serums?
- Choosing the Right Serums for Day and Night
- Daytime Serums
- Nighttime Serums
- Using Different Serums Correctly
- Summing Up
Serums are products that you can apply to your skincare routine. These are a separate category from things like moisturizers and cleansers although they can cleanse and moisturize. They are an essential part of any skincare routine because they provide targeted treatment for specific skin concerns and can use a variety of ingredients to help you achieve targeted results.
That said, it is important that you use your serums correctly especially if you are using different types of serums for face health.
Can I Use Two Different Serums for Day and Night?
Yes! You not only can use two different serums for day and night, but you should.
Benefits of Using Separate Serums for Day and Night
There are several different benefits associated with using separate serums, not least of which is that you can take advantage of the things your skin needs most or the skin's natural processes.
- Daytime Serums: Daytime serums are typically designed to protect the skin from environmental stressors like pollution, UV rays, and free radicals. This means that using them can help protect your skin from things to which you are exposed and may not even realize. These serums use ingredients like Vitamin C, antioxidants, and hyaluronic acid, which are common.
- Nighttime Serums: Night serums focus on repair and hydration, working with the skin's natural overnight regeneration process. This helps to rebuild and repair all of your daytime stress, exposure, and dehydration. These use ingredients like retinol, peptides, and hydrating compounds.
Incorporating night time serums into your skincare routine means that you get to capitalize on the natural regeneration process of your skin and increase hydration and cell turnover for the next day.
Incorporating daytime serums into your skincare routine means that you get to protect yourself against things like wind and environmental stress dehydrating your skin, sunlight causing aging, and other toxins.
Why Separate Serums Are Effective
Using specific serums for day and night allows for targeted treatment that aligns with your skin's needs at different times, optimizing the benefits of each serum.
Can I Use Two Different Serums at the Same Time or Mix Serums?
It is possible to mix serums and use them at the same time, but it's more effective to use separate serums at different times of the day for maximum efficiency.
Why?
Each of the different types of serums you use for your face will contain individual ingredients and be designed to achieve specific purposes so mixing them might deactivate some of the key ingredients in one or the other such that they don't work as well.
It is better to layer them throughout the day, namely, day and night.
Choosing the Right Serums for Day and Night
If you opt to use different serums throughout your day, it's recommended that you layer them, using one in the morning and one in the evening in particular, or that you layer face products like a serum and a moisturizer.
Daytime Serums
Daytime serums should offer protection against things to which your skin is exposed during the day, namely UV rays and pollution. They should also help hydrate your skin so your skin maintains its fullness and plumpness during the day. Look for ingredients like:
- Vitamin C
- Hyaluronic acid
These things protect the skin against environmental damage while retaining moisture.
Example:
- Decree's Protect Elixir: This is perfect for day use, offering essential moisture and protection with ingredients that prevent environmental stress from affecting the skin.
The Decree AM Elixir is designed as an all-in-one day serum. It uses vitamins, minerals, and antioxidants to hydrate, brighten, and protect your skin, all three of which you need throughout the day. For example:
- The daytime serum guards against UV rays and pollution from the sun and the environment
- It has antioxidants and essential minerals to moisturize and plump your skin, so it is visibly improved throughout the day
- There are ingredients that protect against premature aging and help soothe and hydrate the skin without clogging the pores
This type of daytime Decree serum is designed to protect your skin against pollution and stress while also ensuring improved skin resilience and hydration. It can absolutely be combined with other serums or moisturizers as long as it is applied to the skin first and then moisturizers on top.

Nighttime Serums
Night-time serums are designed specifically to focus on cell regeneration and skin repair. These should contain ingredients like:
- Peptides
- Retinol
The active ingredients are designed to work overnight to improve the texture of your skin by reducing hyperpigmentation and fine lines.
Example:
- Decree's Treat Tincture: This is formulated with peptides and antioxidants to support skin renewal while you sleep, ensuring that your skin is hydrated and rejuvenated by morning.
The Decree Treat Tincture is a daily PM serum. This tincture is designed to promote collagen production and hydrate your skin overnight. While you are sleeping it reduces hyperpigmentation, decreases inflammation, tightens your pores and promotes collagen so that when you wake up your skin is rejuvenated and repaired.
Moreover, it works to cleanse the skin more deeply to remove any impurities that accumulated during the day. The tincture in particular helps to reduce signs of aging and promote even skin tone when used at night.
You can combine different types of serums for face health, like this one, applying the Decree serums to your face, neck, lips, and eye area after you have cleansed your face but before you have added something like a moisturizer.
With consistent use, you will see an overall improvement within a few weeks: reduced wrinkles, smoother skin, and better hydration.
Can I use two different serums for day and night?
Absolutely. In fact, this PM tincture is intended to be combined with additional products including a morning serum or something else to treat targeted skin concerns.

Using Different Serums Correctly
Can I use two different serums at the same time, and if so, how should I do it?
If you are going to use different types of serums for your face and neck area, it's important that you layer your serums in the correct order.
Tip: Apply the thinnest serum first, which is usually your daytime serum, and then follow it with thicker, richer night serums.
Can I use two different serums at different times of the day?
Yes! The routine is very similar:
- Day Serum Application: Apply your daytime serum after cleansing and before sunscreen. Choose one with antioxidants or hydration-focused ingredients to protect your skin throughout the day.
- Night Serum Application: After cleansing and toning, apply a night serum that helps with skin repair, like one with retinol or peptides, to support your skin's overnight regeneration.
With consistent use of different face serums, you can see noticeable improvements in the appearance of wrinkles and lines, hyperpigmentation, and more.
Summing Up
With a tailored skincare routine where you use two different serums, one for daytime and one for night time, allows you to provide your skin with optimal care. In fact, if you are going to use different types of serums, it's always best that you have one in the morning and one in the evening that can target different skin needs throughout the day and night.
Explore Decree Serums for the perfect day and night skincare combination.
Discover Dermoi, the only concept store for scientifically-verified skincare. Our expert scientific team performs a thorough analysis of each skincare product, ensuring only the most effective options are available to you. With Dermoi, every item is backed by science, offering transformative benefits for your skin.
Need help with skincare? Our scientific specialists are ready to answer any questions you have. Get in touch via email at [email protected] or give us a call at (0)20 3963 9930, Monday to Friday, from 11am to 4pm.


