The Role of Growth Factors in Skin Care Remodelling and Regeneration
Growth factors are molecules that are naturally occurring in the skin. They play a large role in remodelling and regeneration of the skin tissue after inflammation or injury. They are produced and released from many different cell types within the skin such as fibroblasts, macrophages, keratinocytes, endothelial cells.
Skin Cell Signalling and Processes Induced by Growth Factors
Growth factors allow cells to communicate with other cells in their environment to induce a variety of different processes. Growth factor signalling will stimulate activities such as cell division, cell migration, and gene expression; all of which are involved in the repair and regeneration of the skin.¹
Examples of Growth Factors in Skin Tissue
There are many different growth factors that are secreted in the skin. Some examples of growth factors used in the skin tissue are heparin-binding endothelial growth factor (HB-EGF), fibroblast growth factor (FGF), and transforming growth factor beta 1 and 2 (TGF-B1 & TGF-B2).²
Rejuvenating Effects of Growth Factors Stem Cells in Skin Care
In topical cosmeceutical formulations, growth factors rejuvenate and repair the skin. As growth factors stimulate repair and remodelling of the skin, they can stimulate collagen, elastin, and hyaluronic acid production within the skin to overcome signs of photoaging.
Enhancing Penetration of Growth Factors in Skin
Growth factors are large molecules and traditionally have poor penetration into the skin. They must be combined in sophisticated formulations in order to enhance their penetration into the skin.²
Efficacy of Growth Factors Technology in Reducing Signs of Photoaging
Regardless of this, growth factors have shown to reduce the signs of photoaging including the production of new collagen, epidermal thickening. As well as this they reduce wrinkles, stimulate collagen production and skin cell turnover, when applied to the skin.³⁴⁵
Absorption and Cross Talk of Growth Factors in Skin
Growth factors can be absorbed via sweat glands and hair follicles within the skin. From here they are recognised by keratinocytes in the epidermis which can then signal to fibroblasts in the dermis. This induces a cross talk between the cells for tissue regeneration. In addition, with age, the skin can become more permeable to larger molecules.²
The Power of Growth Factors in Skincare
Experience the revitalizing power of growth factors in skincare. Our growth factor serums, creams and eye serums harnesse the potential of polypeptides to promote skin rejuvenation, reduce signs of aging, and stimulate collagen production. Explore targeted growth factor technology for radiant, youthful skin.
Q&A
What is a growth factor serum, and how does it benefit the skin?
Growth factor serum contains active ingredients that promote skin repair and regeneration. These growth factors stimulate collagen production and improve overall skin health.
Are growth factors in skin care only beneficial for the face?
No, growth factor serums can also be formulated for the delicate skin around the eyes. Growth factor eye serums target specific concerns like fine lines, wrinkles, and dark circles.
How does growth factor hair cream differ from other products?
Growth factor hair creams contain concentrated levels of growth factors specifically designed to promote hair growth and scalp health. These creams nourish the hair follicles, leading to stronger, healthier hair.
References
1. Mehta R, Fitzpatrick R. Endogenous Growth Factors as Cosmeceuticals. Dermatologic Therapy. 2007;20(5):350-359.
2. Husein el Hadmed H, Castillo R. Cosmeceuticals: Peptides, Proteins, and Growth Factors. Journal of Cosmetic Dermatology. 2016;15(4):514-519.
3. Fitzpatrick R, Rostan E. Reversal of Photodamage with Topical Growth Factors: A Pilot Study. Journal of Cosmetic and Laser Therapy. 2003;5(1):25-34.
4. Ehrlich M, Rao J, Pabby A, Goldman M. Improvement in the Appearance of Wrinkles with Topical Transforming Growth Factor β1 and L-Ascorbic Acid. Dermatologic Surgery. 2006;32(5):618-625.
5. de Araújo R, Lôbo M, Trindade K, Silva D, Pereira N. Fibroblast Growth Factors: A Controlling Mechanism of Skin Aging. Skin Pharmacology and Physiology. 2019;32(5):275-282.
