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Why it's Dermoi

Niacinamide is a well-studied active ingredient that has a multitude of skin benefits for all skin types and concerns.

In scientific study, niacinamide has shown improvements in fine lines and wrinkles, redness, dark spots, and acne. Niacinamide inhibits key cellular processes involved in the development of hyperpigmentation and has anti-acne properties that are comparable to topical antibiotics. Niacinamide supports the production of skin barrier lipids and collagen production giving it intense hydrating and anti-wrinkles properties. Niacinamide also provides antioxidant protection against environmental damage.


Niacinamide, also known as vitamin B3, is a water-soluble vitamin with a variety of benefits for the skin.

Niacinamide can improve hyperpigmentation. Hyperpigmentation occurs when there is an uneven distribution of skin pigment (melanin) in the skin. This can occur because of sun exposure (sunspots), acne and inflammation (dark spots), and hormonal changes (melasma). The production of melanin is controlled by a process called melanogenesis. Niacinamide can block melanosome migration between melanocytes and keratinocytes during melanogenesis to brighten the skin and prevent uneven skin tone.

In addition, niacinamide has antibacterial, anti-inflammatory, and sebum balancing properties. In clinical trials, skincare solutions containing 4% niacinamide were comparable to topical antibiotics in their ability to treat acne.²

Niacinamide can support the skin barrier and reduce transepidermal water loss from the skin. This is because the skin barrier is oil based and niacinamide is involved in the production of fatty acids, ceramides, sphingolipids, and free fatty acids.¹ Lastly, niacinamide has powerful antioxidant and anti-aging properties. Niacinamide supports collagen production and has shown to improve fine lines and wrinkles.¹³

In cosmeceutical formulation, niacinamide is stable, non-irritating, and can be easily combined with other active ingredients.


1. Shalita A, Smith J, Parish L, Sofman M, Chalker D. Topical Nicotinamide Compared With Clindamycin Gel in the Treatment of Inflammatory Acne Vulgaris. International Journal of Dermatology. 1995;34(6):434-437.
2. Manela-Azulay M, Bagatin E. Cosmeceuticals Vitamins. Clinics in Dermatology. 2009;27(5):469-474.
3. Bissett D, Oblong J, Berge C. Niacinamide: A B Vitamin that Improves Aging Facial Skin Appearance. Dermatologic Surgery. 2006;31:860-866.

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