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Why it's Dermoi

The skin aging process is extremely complex. Aging results from UV radiation, pollution and stress (extrinsic aging), as well as genetics and hormones (intrinsic aging).

Menopause causes a large increase of intrinsic aging in women. This is because post-menopause, most women suffer a massive drop in the hormone estrogen. Estrogen plays a role in various processes throughout the whole body, and its receptors (ERα + ERβ) are found on various cell types. Within the skin, estrogen can bind and influence cells such as the epidermal keratinocytes, dermal fibroblasts, and melanocytes.

During perimenopause and menopause, most women experience Estrogen Deficient Skin (EDS).

After the age of 20, estrogen levels fall every year and with it falls elastin, collagen and moisture levels. Estrogen is a crucial hormone in maintaining healthy and vibrant skin because it activates estrogen receptors in skin cells to produce elastin and collagen. It also helps to increase cell turnover, which gives the appearance of plump and youthful-looking skin.

Within the first 5 years of menopause, skin collagen levels decrease by 30%.
In each subsequent year of menopause, skin collagen levels decrease by 1%.
In each postmenopausal year, skin thickness declines by 1%.

In summary, menopause causes rapid skin aging, but you can target these premature aging effects with the advanced skincare formulations below.


Menopause is a natural phase in the life of most females over 40 and has many effects all over the body. In terms of the skin, menopause leads to wrinkles, dark circles, acne, dryness, itchiness, hot flashes and many other processes all because of hormonal changes within the body. This is all because of a decline in the hormone, estrogen.

Estrogen Deficient Skin is unable to protect itself against oxidative stress as it normally would. Resultantly, this means that collagen production decreases and skin becomes thinner, leading to increased wrinkling, decreased elasticity and decreased moisture.

Because of thinner and drier skin, dark blood vessels beneath the skin become more visible, which leads to the formation of dark circles under the eyes. This is worsened by dehydration and sun overexposure.


1. Bensaleh H, Belhnaoui FZ, Douira L, Berbiche L, Senouci K, & Hassam B. (2006) Skin and Menopause. Annales d'Endocrinologie . 67(6), 575-580.
2. Cohen JL. (2019) Evaluation of Efficacy of a Skincare Regimen Containing Methyl Estradiolpropanoate (MEP) for Treating Estrogen Deficient Skin. Journal of Drugs in Dermatology. 18(12), JO01219.
3. Raine-Fenning NJ, Brincat MP, & Muscat-Baron Y. (2003) Skin Aging and Menopause. American Journal of Clinical Dermatology. 4, 371-378.
4. Rzepecki A, Murase J, Juran R, Fabi S, McLellan B. Estrogen-Deficient Skin: The Role of Topical Therapy. International Journal of Women's Dermatology. 2019;5(2):85-90.

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